Herpes simplex virus (HSV) is classified in the alpha virinae subfamily within the family Herpesviridae. Two "closely-related viruses are designated HSV types 1 and 2. HSV-1 is the usual cause of orolabial infection "(gingivostomatitis or herpes labialis), whereas HSV-2 is the major cause of genital infection. However, either virus can "infect either location. "Several modalities are available for the diagnosis of HSV infections. Serology can establish current and past infection "with HSV. It has also been used in research studies of the epidemiology of HSV and is very useful in unusual clinical "situations".
The antibody response to HSV glycoprotein G (gG) is highly specific, and gG-based assays can accurately determine "whether individuals have past infection with HSV-1 and/or HSV-2. Because genital HSV-2 infection is much more likely "to recur than genital HSV-1 infection, the presence of antibody to HSV-2 and a compatible clinical history would "be strong presumptive evidence that the disease was recurrent genital herpes. Testing of pregnant women for HSV "antibodies is usually done with a type-specific assay for HSV antibodies "Clinical Information "Immunoperoxidase staining for herpes simplex virus (HSV) I and II produces nuclear and granular cytoplasmic "staining of virus infected cells. HSV I and II are part of the herpes virus family that also includes Epstein Barr virus, "herpes zoster, and cytomegalovirus. HSV are among the most common infectious agents of man and usually are "transmitted through close personal contact. The manifestations of infection can be localized (oral lesions HSV I; "genital lesions HSV II) or can cause life-threatening systemic infection in immunocompromised patients.
Herpes simplex virus (HSV) types 1 and 2 are members of the Herpesviridae family and produce infections that may "range from mild stomatitis to disseminated and fatal disease. Clinical conditions associated with HSV infection "include gingivostomatitis, keratitis, encephalitis, vesicular skin eruptions, aseptic meningitis, neonatal herpes, genital "tract infections, and disseminated primary infection.
Though in most cases HSV-II shows no symptoms, below are some of the most symptoms associated with it.
Fever Blisters/ Cold Sores
Pain or Itching at the affected area
A clinical diagnosis of HSV-II is critical and should be confirmed by laboratory testing, for accurate results, this can be accomplished by using direct tests for detection of HSV DNA– uses molecular diagnostic techniques, electron microscopy, viral isolation, Tzanck smears, and detection of antigens among other tests.
HSV-II Test Results Using IgG
Upon receiving herpes test results using IgG, you are likely to get a number value. The HSV II test results range may be
Negative; 0.90 IV or less
Equivocal; 0.91-1.09 IV
Positive; 1.10 IV or more