Calprotectin is a calcium-containing protein that makes up 5% of the total protein and 60% of the cytosolic protein of neutrophils. It has bacteriostatic and fungistatic properties and is found in feces at levels six times higher than that in plasma. That fecal biomarker is useful to assess the activity of inflammatory bowel disease (IBD). IBD includes Crohn's Disease (CD) and Ulcerative Colitis (UC) and are associated with elevated neutrophils.
This fecal calprotectin assay is useful in differentiating organic (IBD) from functional gastrointestinal disease (IBS: Intestinal Bowel Syndrome). It is a simple, non-invasive biomarker that is especially useful in children, who may require general anesthesia for colonoscopy. And this fecal calprotectin detection can predict relapse.
Calprotectin Rapid Test Cassette (Faeces) is a rapid chromatographic immunoassay for the qualitative detection of Calprotectin in human faeces specimen which might be useful for the diagnosis of inflammatory gastrointestinal disorders.
Calprotectin is a 24 kDa dimer of calcium binding proteins S100A8 and S100A9. The complex accounts for up to 60% of the soluble protein content of the neutrophil cytosol. Calprotectin becomes available in the intestinal lumen via leukocyte shedding, active secretion, cell disturbance, and cell death. This results in elevated faecal calprotectin levels, which can be detected in the stool.
Elevated faecal calprotectin levels therefore indicate migration of neutrophils into the intestinal mucosa, which occurs during intestinal inflammation.[4] Faecal calprotectin has been used to detect intestinal inflammation and can serve as a marker for inflammatory bowel diseases. Calprotectin is useful as a marker, as it is resistant to enzymatic degradation, and can be easily measured in faeces
MATERIALS Provided: Test cassettes, Package insert, Specimen collection tube with extraction buffer. Not Provided but required: Specimen collection/stool containers, Timer, Droppers.
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